Now in its sixth edition, The American Psychiatric Association Publishing Textbook of Psychopharmacology remains the field's most comprehensive guide to the theory and practice of psychopharmacology. This extensively updated new edition features the expertise of more than 160 contributors, including more than 75 new authors. Twelve new chapters have been added to cover important key areas in this rapidly evolving specialty, including personalized medicine in psychiatry; the role of artificial intelligence and machine learning in the field; new agents with novel mechanisms, such as the neurosteroid antidepressant brexanolone and the atypical antipsychotic pimavanserin; use of investigational agents, such as psychedelics, in psychiatric treatment; evidencebased treatment of PTSD, OCD, autism spectrum disorder, and alcohol use disorder; and much more. Noteworthy additions to this textbook include chapters addressing the following topics: * The potential roles of personalized medicine in psychiatry and of artificial intelligence and machine learning in psychopharmacology* New medications with novel pharmacological mechanisms, including the neurosteroid antidepressant brexanolone and the atypical antipsychotic pimavanserin* Use of investigational agents, such as psychedelics, in psychiatric treatment* Treatment of alcohol use disorder, PTSD, OCD, and autism spectrum disorderWith a level of detail not found in any other source, this new edition of The American Psychiatric Association Publishing Textbook of Psychopharmacology illuminates the path to effective evidencebased practice of psychopharmacology for novice and seasoned clinicians alike.