Description
Foreword - Lorraine Nicolle. Part One - Mitochondria: The doorway to understanding the body as a whole. 1. What are mitochondria? 2. Evolution and mitochondria. 3. Energy production. 4. Mitochondrial dynamics: Shape-shifting mitochondria on the move. 5. Mitochondria: The original multi-fuel burners and the need for metabolic flexibility. 6. Acetyl-CoA: Much more than an energy source. 7. Catabolic and anabolic: How mitochondria initiate the change from burning fuel to cell building. 8. Ketone metabolism. 9. Mitochondria and the immune system. 10. Creatine: The mitochondrial ATP assistant. 11. Calcium and mitochondria: Conductors of the cell 'orchestra'. 12. Apoptosis: (Programmed cell death). 13. Iron and mitochondria: A matter of life and death. 14. Urea: Liver mitochondria help to clear ammonia. 15. Health, toxicity and hormesis. Part Two - The influence of mitochondria in disease. 16. Insulin resistance and type 2 diabetes. 17. Hypertension. 18. The heart. 19. Cholesterol metabolism. 20. Autoimmunity and mitochondria: The emerging field of immunometabolism. 21. Fatigue. 22. Neurodegeneration. 23. Cancer. 24. Osteoarthritis. 25. Osteoporosis. 26. Chronic Pain. 27. Depression. 28. Autism Spectrum Disorders.